Rapid advances in nanopore technologies for sequencing single long DNA and RNA
molecules have led to substantial improvements in accuracy, read length and throughput …

Transposable elements (TEs) are mobile DNA sequences that propagate within genomes.
Through diverse invasion strategies, TEs have come to occupy a substantial fraction of …

Conifers dominate the world's forest ecosystems and are the most widely planted tree
species. Their giant and complex genomes present great challenges for assembling a …

Existing long-read assemblers require thousands of central processing unit hours to
assemble a human genome and are being outpaced by sequencing technologies in terms of …

The increasing application of RNA sequencing to study non-model species demands easy-
to-use and efficient bioinformatics tools to help researchers quickly uncover biological and …

Accurate genome assembly is hampered by repetitive regions. Although long single
molecule sequencing reads are better able to resolve genomic repeats than short-read data …

In less than 25 y, the field of animal genome science has transformed from a discipline
seeking its first glimpses into genome sequences across the Tree of Life to a global …

Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …

Chromosomal aberrations including structural variations (SVs) are a major cause of human
genetic diseases. Their detection in clinical routine still relies on standard cytogenetics …

Several new genomics technologies have become available that offer long-read sequencing
or long-range mapping with higher throughput and higher resolution analysis than ever …