RNA binding proteins that act at the post-transcriptional level display a richness of
mechanisms to modulate the transcriptional output and respond to changing cellular …

Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

In neurons, dendritic protein synthesis is required for many forms of long-term synaptic
plasticity. The population of mRNAs that are localized to dendrites, however, remains …

The elaborate morphology of neurons together with the information processing that occurs in
remote dendritic and axonal compartments makes the use of decentralized cell biological …

We describe a method for imaging individual mRNA molecules in fixed cells by probing
each mRNA species with 48 or more short, singly labeled oligonucleotide probes. This …

Dendritic spines are small protrusive structures on dendritic surfaces, and function as
postsynaptic compartments for excitatory synapses. Plasticity of spine structure is associated …

The transport of mRNAs to distal subcellular compartments is an important component of
spatial gene expression control in neurons. However, the mechanisms that control mRNA …

The localization of mRNAs to subcellular compartments provides a mechanism for
regulating gene expression with exquisite temporal and spatial control. Recent studies …

Fragile X syndrome is the most common inherited form of cognitive deficiency in humans
and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion …