Angiotensin II type 1 receptor antagonists (ARBs) have become an important drug class in
the treatment of hypertension and heart failure and the protection from diabetic nephropathy …

We have reviewed the effects of angiotensin II type 1 receptor antagonists (ARBs) in various
animal models of hypertension, atherosclerosis, cardiac function, hypertrophy and fibrosis …

The aim of the present study was to evaluate the effects of monotherapies and combinations
of drugs on insulin sensitivity, adipose tissue morphology, and pancreatic and hepatic …

Telmisartan shows antihypertensive and several pleiotropic effects that interact with
metabolic pathways. In the present study we tested the hypothesis that telmisartan prevents …

Obesity is a well‐known risk factor for the development of secondary complications such as
type 2 diabetes. However, only a part of the obese population develops secondary …

Aim To evaluate the effects of single PPARα or PPARγ activation, and their synergism
(combined PPARα/γ activation) upon the gut-adipose tissue axis, focusing on the …

An epidemic of metabolic diseases including type 2 diabetes and obesity is undermining the
health of people living in industrialized societies. There is an urgent need to develop …

Importance of the field: PPARγ full agonists (pioglitazone and rosiglitazone) are the
mainstay drugs for the treatment of type 2 diabetes; however, mechanism-based side effects …

The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial
(ONTARGET™) showed that the angiotensin II receptor blocker (ARB) telmisartan was as …

The klotho gene may be involved in the aging process. Klotho is a coactivator of FGF23, a
regulator of phosphate and vitamin D metabolism. It has also been reported to be …