The physiology of lactoferrin

JH Brock - Biochemistry and Cell biology, 2002 - cdnsciencepub.com
Cet article fait une revue de nos connaissances actuelles concernant la structure et la
fonction de la lactoferrine, une protéine liant le fer. Il tente spécialement d'établir une relation …

Multi-copper oxidases and human iron metabolism

G Vashchenko, RTA MacGillivray - Nutrients, 2013 - mdpi.com
Multi-copper oxidases (MCOs) are a small group of enzymes that oxidize their substrate with
the concomitant reduction of dioxygen to two water molecules. Generally, multi-copper …

The biology of mammalian multi-copper ferroxidases

SL Helman, J Zhou, BK Fuqua, Y Lu, JF Collins… - Biometals, 2023 - Springer
The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH)
and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron …

Molecular evolution of the transferrin family and associated receptors

LA Lambert - Biochimica et Biophysica Acta (BBA)-General Subjects, 2012 - Elsevier
BACKGROUND: In vertebrates, serum transferrins are essential iron transporters that have
bind and release Fe (III) in response to receptor binding and changes in pH. Some family …

Regulation of iron pathways in response to hypoxia

NL Chepelev, WG Willmore - Free Radical Biology and Medicine, 2011 - Elsevier
Constituting an integral part of a heme's porphyrin ring, iron is essential for supplying cells
and tissues with oxygen. Given tight links between oxygen delivery and iron availability, it is …

Lactoferrin and cancer disease prevention

L Rodrigues, J Teixeira, F Schmitt… - Critical reviews in …, 2008 - Taylor & Francis
Lactoferrin (LF) is an iron-binding glycoprotein that is composed of the transferrin family and
is predominantly found in the products of the exocrine glands located in the gateways of the …

Lactoferrin: From the structure to the functional orchestration of iron homeostasis

G Ianiro, L Rosa, MC Bonaccorsi di Patti, P Valenti… - Biometals, 2023 - Springer
Iron is by far the most widespread and essential transition metal, possessing crucial
biological functions for living systems. Despite chemical advantages, iron biology has forced …

Looking for a partner: ceruloplasmin in protein–protein interactions

VB Vasilyev - Biometals, 2019 - Springer
Ceruloplasmin (CP) is a mammalian blood plasma ferroxidase. More than 95% of the
copper found in plasma is carried by this protein, which is a member of the multicopper …

Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin

ET Zakharova, AV Sokolov, NN Pavlichenko… - Biometals, 2018 - Springer
Among the properties of lactoferrin (LF) are bactericidal, antianemic, immunomodulatory,
antitumour, antiphlogistic effects. Previously we demonstrated its capacity to stabilize in vivo …

Lactoferrin, myeloperoxidase, and ceruloplasmin: complementary gearwheels cranking physiological and pathological processes

AV Sokolov, ET Zakahrova, VA Kostevich… - Biometals, 2014 - Springer
Copper-containing plasma protein ceruloplasmin (Cp) forms a complex with lactoferrin (Lf),
an iron-binding protein, and with the heme-containing myeloperoxidase (Mpo). In case of …