Genome-wide association study has identified fruitful variants impacting heritable traits.
Nevertheless, identifying critical genes underlying those significant variants has been a …

Systemic lupus erythematosus is a heritable autoimmune disease that predominantly affects
young women. To improve our understanding of genetic etiology, we conduct multi-ancestry …

The process of drug development is expensive and time-consuming. In contrast, drug
repurposing can be introduced to clinical practice more quickly and at a reduced cost. Over …

Splicing-based transcriptome-wide association studies (splicing-TWASs) of breast cancer
have the potential to identify susceptibility genes. However, existing splicing-TWASs test the …

Exploring new therapeutic diseases for existing drugs plays an essential role in reducing
drug development costs. However, existing methods for predicting drug–disease association …

Background MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression.
Differential miRNA expression, which is widely shown to be associated with the …

Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-
specific epigenomic annotations and 3D genome information we generated and validated …

Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world.
Genetic factors influence smoking behaviours and although strides have been made using …

Human genetics has emerged as one of the most dynamic areas of biology, with a
broadening societal impact. In this review, we discuss recent achievements, ongoing efforts …

Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world.
Genetic factors influence smoking behaviors, and although strides have been made using …