Pulsatile secretion of gonadotropin-releasing hormone (GnRH) is essential for activating
and maintaining the function of the hypothalamic–pituitary–gonadal axis, which controls the …

Amyloid-beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease.
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …

Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer's
disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is …

Alzheimer's disease is the most common type of dementia, being highly prevalent in elderly
women. The advanced progression may be due to decreased hormone synthesis during …

Dementia, especially Alzheimer's disease, presents a major clinical challenge, and
researchers are still searching for an optimal animal model. To address this gap, we …

Objective Childhood cancer survivors are at risk for hypogonadism. The impact of
hypogonadism on neurocognitive impairment and emotional distress in the non-cancer …

Functional and structural neuronal networks, as recorded by resting-state functional MRI and
diffusion MRI-based tractography, gain increasing attention as data driven whole brain …

Pulsatile secretion of gonadotropin‐releasing hormone (GnRH) is essential for the activation
and maintenance of the function of the hypothalamic–pituitary‐gonadal (HPG) axis, which …

INTRODUCTION Premenopausal bilateral oophorectomy (PBO) before the age of 46 years
is associated with an increased risk of dementia. We investigated the long‐term effects of …

INTRODUCTION Premenopausal bilateral oophorectomy (PBO) is associated with later‐life
cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO …