Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Necroptosis is a form of regulated cell death that critically depends on receptor-interacting
serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and …

Necroptosis | New England Journal of Medicine Skip to main content The New England Journal
of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical Medicine …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Microglia and macrophages in the CNS contain multimolecular complexes termed
inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as …

Cell proliferation and cell death are integral elements in maintaining homeostatic balance in
metazoans. Disease pathologies ensue when these processes are disturbed. A plethora of …

Drug-induced liver injury (DILI) occurs in an incidence of 10 to 15 in 10, 000 to 100,000 in
the United States, 1, 2 yet it has caused remarkable fatalities from acute liver failure yearly …

Innate immunity represents the first line of defence against invading pathogens. It consists of
an initial inflammatory response that recruits white blood cells to the site of infection in an …

Perinatal insults such as hypoxia–ischemia induces secondary brain injury. In order to
develop the next generation of neuroprotective therapies, we urgently need to understand …