Abstract Recently, Chromosome Conformation Capture (3C) based experiments have
highlighted the importance of computational models for the study of chromosome …

Chromosome conformation capture (3C) and fluorescence in situ hybridization (FISH) are
two widely used technologies that provide distinct readouts of 3D chromosome organization …

Repair of a chromosomal double-strand break (DSB) by gene conversion depends on the
ability of the broken ends to encounter a donor sequence. To understand how chromosomal …

For eukaryotic cells, the biological processes involving regulatory DNA elements play an
important role in cell cycle. Understanding 3D spatial arrangements of chromosomes and …

Restraint-based modeling of genomes has been recently explored with the advent of
Chromosome Conformation Capture (3C-based) experiments. We previously developed a …

High-resolution three-dimensional models of Caulobacter crescentus nucleoid structures
were generated via a multi-scale modeling protocol. Models were built as a plectonemically …

The three dimensional organization of genomes remains mostly unknown due to their high
degree of condensation. Biophysical studies predict that condensation promotes the …

Non-random, dynamic three-dimensional organization of the nucleus is important for
regulation of gene expression. Numerous studies using chromosome conformation capture …

Background The three-dimensional (3D) configuration of chromosomes within the eukaryote
nucleus is an important factor for several cellular functions, including gene expression …

The spatial organization of the genome influences cellular function, notably gene regulation.
Recent studies have assessed the three-dimensional (3D) co-localization of functional …