Metabotropic glutamate receptors: from the workbench to the bedside
Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …
Ischemic postconditioning as a novel avenue to protect against brain injury after stroke
H Zhao - Journal of Cerebral Blood Flow & Metabolism, 2009 - journals.sagepub.com
Ischemic postconditioning initially referred to a stuttering reperfusion performed immediately
after reperfusion, for preventing ischemia/reperfusion injury in both myocardial and cerebral …
after reperfusion, for preventing ischemia/reperfusion injury in both myocardial and cerebral …
Group I metabotropic glutamate receptor signalling and its implication in neurological disease
F M. Ribeiro, M Paquet, S P. Cregan… - CNS & Neurological …, 2010 - benthamdirect.com
Stimulation of Group I metabotropic glutamate receptors (mGluR1 and mGluR5) leads to
activation of a wide variety of signalling pathways. mGluRs couple to Gαq/11 proteins …
activation of a wide variety of signalling pathways. mGluRs couple to Gαq/11 proteins …
Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury
PD Loetscher, J Rossaint, R Rossaint, J Weis, M Fries… - Critical care, 2009 - Springer
Introduction Recently, it has been shown in several experimental settings that the noble
gases xenon and helium have neuroprotective properties. In this study we tested the …
gases xenon and helium have neuroprotective properties. In this study we tested the …
From rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemia
Ischemic postconditioning is a concept originally defined to contrast with that of ischemic
preconditioning. While both preconditioning and postconditioning confer a neuroprotective …
preconditioning. While both preconditioning and postconditioning confer a neuroprotective …
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer
Metabotropic glutamate receptors are G-protein-coupled receptors normally expressed in
the central nervous system where they mediate neuronal excitability, synaptic plasticity, and …
the central nervous system where they mediate neuronal excitability, synaptic plasticity, and …
Excitatory and inhibitory amino acid neurotransmitters in stroke: from neurotoxicity to ischemic tolerance
Highlights•Clinical trials with neuroprotective drugs have failed in stroke.•Glutamate and
GABA crucially contribute to ischemic pathobiology.•Grabbing glutamate or targeting …
GABA crucially contribute to ischemic pathobiology.•Grabbing glutamate or targeting …
[HTML][HTML] Ischemic postconditioning exerts neuroprotective effect through negatively regulating PI3K/Akt2 signaling pathway by microRNA-124
W Miao, Y Yan, T Bao, W Jia, F Yang, Y Wang… - Biomedicine & …, 2020 - Elsevier
Ischemic stroke is a serious threat to human life and health, which is often accompanied by
cerebral ischemia-reperfusion (I/R) injury in clinic. Ischemic postconditioning (IPostC) is a …
cerebral ischemia-reperfusion (I/R) injury in clinic. Ischemic postconditioning (IPostC) is a …
Post‐ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy
Because clinical trials of pharmacological neuroprotective strategies in stroke have been
disappointing, attention has turned to the brain's own endogenous strategies for …
disappointing, attention has turned to the brain's own endogenous strategies for …
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?
Moving from early studies, we here review the most recent evidence linking metabotropic
glutamate (mGlu) receptors to processes of neurodegeneration/neuroprotection. The use of …
glutamate (mGlu) receptors to processes of neurodegeneration/neuroprotection. The use of …