Given the role of intermediate filaments (IFs) in normal cell physiology and scores of IF-
linked diseases, the importance of understanding their molecular structure is beyond doubt …

The cytoskeleton of the eukaryotic cell provides a structural and functional scaffold enabling
biochemical and cellular functions. While actin and microtubules form the main framework of …

Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and
mechanics and mutated in a wide range of human diseases. Yet little is known about the …

To characterize keratin intermediate filament assembly mechanisms at atomic resolution, we
determined the crystal structure of wild‐type human keratin‐1/keratin‐10 helix 1B …

The assembly of intermediate filaments (IFs) including nuclear lamins is driven by specific
interactions of the elementary coiled-coil dimers in both lateral and longitudinal direction …

Intermediate filaments (IFs), together with microtubules and actin microfilaments, are the
three main cytoskeletal components in metazoan cells. IFs are formed by a distinct protein …

Motivation Accurate molecular structure of the protein dimer representing the elementary
building block of intermediate filaments (IFs) is essential towards the understanding of the …

The molecular architecture and assembly mechanism of intermediate filaments have been
enigmatic for decades. Among those, lamin filaments are of particular interest due to their …

We previously determined the crystal structure of the wild-type keratin 1/10 helix 2B
heterodimer at 3.3 Å resolution. We proposed that the resolution of the diffraction data was …

Vimentin is an intermediate filament (IF) protein that is expressed in leukocytes, fibroblasts
and endothelial cells of blood vessels. Vimentin filaments contribute to structural stability of …