Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel

PT Nguyen, KR DeMarco, I Vorobyov… - Proceedings of the …, 2019 - National Acad Sciences
The human voltage-gated sodium channel, hNaV1. 5, is responsible for the rapid upstroke of
the cardiac action potential and is target for antiarrhythmic therapy. Despite the clinical …