The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Excess dietary salt is a major cause of hypertension. Nevertheless, the specific mechanisms
by which salt increases arterial constriction and peripheral vascular resistance, and thereby …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

The present review first summarizes the complex chain of events, in endothelial and
vascular smooth muscle cells, that leads to endothelium-dependent relaxations …

Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …

In human coronary arterioles (HCAs) from patients with coronary artery disease, flow-
induced dilation is mediated by a unique mechanism involving the release of H2O2 from the …

Endothelial cells and smooth muscle cells of resistance arteries mediate opposing
responses to mechanical forces acting on the vasculature, promoting dilation in response to …

Cellular processes are initiated and regulated by different stimuli, including mechanical
forces. Cell membrane mechanosensors represent the first step towards the conversion of …

The endothelium controls vascular tone not only by releasing various vasoactive substances
but also by another pathway associated with the hyperpolarization of both endothelial and …