Background Implantable cardioverter-defibrillators (ICDs) are implanted with the intention to
prolong life in selected patients with inherited arrhythmia syndromes, but ICD implantation is …

Over the past decade, next-generation sequencing (NGS) has led to an exponential
increase in our understanding of the genetic basis of Mendelian diseases. NGS allows for …

Ongoing challenges of clinical assessment of long QT syndrome (LQTS) highlight the
importance of genetic testing in the diagnosis of asymptomatic at‐risk family members …

Abstract Aims It is Class I recommendation that congenital long QT syndrome (cLQTS)
patients should avoid drugs that can cause torsades de pointes (TdP). We determined use of …

Background The efficacy of cascade screening for the inherited heart conditions long QT
syndrome (LQTS) and hypertrophic cardiomyopathy (HCM) is incompletely characterized …

Background The role of multidisciplinary clinics for psychosocial care is increasingly
recognized for those living with inherited cardiac conditions (ICC). In Canada, access to …

For all of us working in the field of inherited heart conditions, our ultimate aim is the
prevention of sudden cardiac death in young people in our communities. We share the …

Long QT syndrome is the most commonly recognised cause of sudden cardiac death in
children. With a prevalence of 1 in 2000, family screening is identifying large numbers of …

Abstract Background Long QT syndrome (LQTS) is a cardiac ion channelopathy which
presents clinically with palpitations, syncope or sudden death. More than 700 LQTS-causing …

Interest in the familial aspects of disability has heightened in recent years. Three forms of
disability—hearing loss, Fragile X syndrome, and autism spectrum disorders—are used here …