Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …

Three-dimensional cell cultures using patient-derived stem cells are essential in vitro
models for a more efficient and individualized cancer therapy. Currently, culture conditions …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …

Osteosarcoma (OS) is the most common type of bone tumor that seriously affects limb
function and induces great pain in patients. Lung metastasis and chemotherapy resistance …

Developing strategies to activate tumor-cell-intrinsic immune response is critical for
improving tumor immunotherapy by exploiting tumor vulnerability. KDM4A, as a histone H3 …

Histone methylation plays a key function in modulating gene expression, and preserving
genome integrity and epigenetic inheritance. However, aberrations of histone methylation …

Basal-like breast cancers (BLBC) are characterized by defects in homologous
recombination (HR), deficient mitotic checkpoint, and high-proliferation activity. Here, we …

Growing evidence has demonstrated that epigenetic dysregulation is a common
pathological feature in human cancer cells. Global alterations in the epigenetic landscape …