Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations

C Sun, CO Swoboda, FM Morales, C Calvo… - Nature …, 2024 - nature.com
Multinucleated skeletal muscle cells need to acquire additional nuclei through fusion with
activated skeletal muscle stem cells when responding to both developmental and adaptive …

Functional specialisation and coordination of myonuclei

A Korb, S Tajbakhsh, GE Comai - Biological Reviews, 2024 - Wiley Online Library
Myofibres serve as the functional unit for locomotion, with the sarcomere as fundamental
subunit. Running the entire length of this structure are hundreds of myonuclei, located at the …

The expanding roles of myonuclei in adult skeletal muscle health and function

AK Borowik, KA Murach, BF Miller - Biochemical Society …, 2024 - portlandpress.com
Skeletal muscle cells (myofibers) require multiple nuclei to support a cytoplasmic volume
that is larger than other mononuclear cell types. It is dogmatic that mammalian resident …

[HTML][HTML] Lineage tracing of newly accrued nuclei in skeletal myofibers uncovers distinct transcripts and interplay between nuclear populations

C Sun, CO Swoboda, MJ Petrany, S Parameswaran… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Multinucleated skeletal muscle cells have an obligatory need to acquire additional nuclei
through fusion with activated skeletal muscle stem cells when responding to both …

Myonuclear apoptosis underlies diaphragm atrophy in mechanically ventilated ICU patients

WJ Claassen, M van den Berg, ZH Shi, RJ Baelde… - medRxiv, 2024 - medrxiv.org
Rationale Mechanical ventilation plays an important role in critical illness-associated
diaphragm weakness. Weakness contributes to difficult weaning and is associated with …

Effect of Sijunzi Decoction on the Myonuclear Domain of Rat Soleus in Spleen Qi Deficiency

L Zhang, D Ma, S Wang, X Liu, L Wang… - Chinese …, 2023 - eprints.go4mailburst.com
Objective: To study the mechanism of Sijunzi decoction treating limb weakness in spleen Qi
deficiency (SQD) based on the myonuclear domain (MND) theory. Methods: 40 male …

Epigenetic Regulation of Muscle Cell Fate and Identity

K Sahinyan - 2024 - escholarship.mcgill.ca
Les muscles squelettiques possèdent une capacité de régénération remarquable et sont
capable de s' adapter en réponse aux stimuli. La régénération des muscles est assurée par …

Postsynaptic BMP Signaling Instructs Myonuclear Properties to Support Neuromuscular Junction Activity

V von Saucken - 2024 - search.proquest.com
A mammalian skeletal muscle fiber is a large, multinucleated cell with a diverse nuclear
population. Each (myo) nucleus has a distinct position along the fiber, and those adjacent to …

[引用][C] Multinucleation as a buffer against gene expression noise in syncytial myofibres

KA Hansson - The Journal of Physiology - Wiley Online Library
Skeletal muscle fibres, or myofibres, are exceptional for their vast size and complex
multinucleated structure. Formed by the fusion of individual myoblasts, these syncytial cells …