Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …

R-spondin (RSPO) proteins constitute a family of four secreted glycoproteins (RSPO1–4)
that have appeared as multipotent signaling ligands. The best-known molecular function of …

For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …

The four vertebrate R-spondin proteins are secreted agonists of the canonical Wnt/β-catenin
signaling pathway. These proteins are approximately 35 kDa, and are characterized by two …

After its discovery as oncogen and morphogen, studies on Wnt focused initially on its role in
animal development. With the finding that the colorectal tumour suppressor gene APC is a …

Wnt signalling is involved in multiple aspects of embryonic development and adult tissue
homeostasis, notably via controlling cellular proliferation and differentiation. Wnt signalling …

Recently, the R-spondin (RSPO) family of proteins has emerged as important regulators of
WNT signaling. Considering the wide spectrum of WNT signaling functions in normal …

This chapter provides the scientific backdrop to the interpretation and understanding of
many diseases of the nails and their management. Embryogenesis represents the original …

Activation of Wnt signaling leads to high bone density. The R-spondin family of four secreted
glycoproteins (Rspo1-4) amplifies Wnt signaling. In humans, RSPO3 variants are strongly …

R-spondins (RSPOs) are a family of cysteine-rich secreted proteins containing a single
thrombospondin type I repeat (TSR) domain. A vast amount of information regarding cellular …