Mechanisms underlying mutational signatures in human cancers
The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …
mutagenic processes that have been operative over the lifetime of a patient. Each process …
Arsenic-induced oxidative stress and its reversibility
SJS Flora - Free Radical Biology and Medicine, 2011 - Elsevier
This review summarizes the literature describing the molecular mechanisms of arsenic-
induced oxidative stress, its relevant biomarkers, and its relation to various diseases …
induced oxidative stress, its relevant biomarkers, and its relation to various diseases …
High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes
H Rizwan, S Pal, S Sabnam, A Pal - Life sciences, 2020 - Elsevier
Mitochondria are fascinating structures of the cellular compartments that generate energy to
run the cells. However, inherent disorders of mitochondria due to diabetes can cause major …
run the cells. However, inherent disorders of mitochondria due to diabetes can cause major …
[HTML][HTML] Environmental arsenic exposure: from genetic susceptibility to pathogenesis
More than 200 million people in 70 countries are exposed to arsenic through drinking water.
Chronic exposure to this metalloid has been associated with the onset of many diseases …
Chronic exposure to this metalloid has been associated with the onset of many diseases …
Base excision repair and cancer
SS Wallace, DL Murphy, JB Sweasy - Cancer letters, 2012 - Elsevier
Base excision repair is the system used from bacteria to man to remove the tens of
thousands of endogenous DNA damages produced daily in each human cell. Base excision …
thousands of endogenous DNA damages produced daily in each human cell. Base excision …
Portrait of a cancer: mutational signature analyses for cancer diagnostics
Background In the past decade, systematic and comprehensive analyses of cancer
genomes have identified cancer driver genes and revealed unprecedented insight into the …
genomes have identified cancer driver genes and revealed unprecedented insight into the …
Phenolic compounds of blueberries (Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: A review of antioxidant potential and …
The skin is a tissue with a high metabolic activity that acts as a protective layer for the
internal organs of the body. This tissue is exposed to a variety of damaging agents, including …
internal organs of the body. This tissue is exposed to a variety of damaging agents, including …
Biomarkers of oxidative stress and damage in human populations exposed to arsenic
Arsenic (As) is an ubiquitous element in the environment for which the main route of human
exposure is through consumption of drinking water. Reactive oxygen species generation …
exposure is through consumption of drinking water. Reactive oxygen species generation …
Cr (VI)-induced methylation and down-regulation of DNA repair genes and its association with markers of genetic damage in workers and 16HBE cells
G Hu, P Li, X Cui, Y Li, J Zhang, X Zhai, S Yu… - Environmental …, 2018 - Elsevier
To examine the mechanism of hexavalent chromium [Cr (VI)]-induced carcinogenesis, a
cross-sectional study in workers with or without exposure to Cr (VI) as well as in vitro …
cross-sectional study in workers with or without exposure to Cr (VI) as well as in vitro …
Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity
A Bravard, M Vacher, E Moritz, L Vaslin, J Hall, B Epe… - Cancer research, 2009 - AACR
The hOGG1 gene encodes the DNA glycosylase that removes the mutagenic lesion 7, 8-
dihyro-8-oxoguanine (8-oxoG) from DNA. A frequently found polymorphism resulting in a …
dihyro-8-oxoguanine (8-oxoG) from DNA. A frequently found polymorphism resulting in a …