Lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis
involve the progressive and inexorable destruction of oxygen exchange surfaces and …

We identify in this article a new class of lung tissue-resident memory CD4 T cells that exhibit
tissue tropism and retention independent of Ag or inflammation. Tissue-resident memory …

The extent to which tissue-specific viral infections generate memory T cells specifically
adapted to and maintained within the target infection site is unknown. Here, we show that …

Targeted therapies have demonstrated efficacy against specific subsets of molecularly
defined cancers,,,. Although most patients with lung cancer are stratified according to a …

There is a pressing need to develop alternatives to annual influenza vaccines and antiviral
agents licensed for mitigating influenza infection. Previous studies reported that acute lung …

Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized
by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a NAD+ …

The prevention and treatment of acute chest syndrome (ACS) is a major clinical concern in
sickle cell disease (SCD). However, the mechanism underlying the pathogenesis of ACS …

Many milestones in medical history rest on animal modeling of human diseases. The SARS-
CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical …

Memory CD4 T cells specific for influenza virus are generated from natural infection and
vaccination, persist long-term, and recognize determinants in seasonal and pandemic …

Background Influenza A viruses cause life-threatening pneumonia and lung injury in the
lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown …