Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the
presence of hypervascularization and necrosis, both caused by a hypoxic …

Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

The overall response rate for anti–PD-1 therapy remains modest in hepatocellular
carcinoma (HCC). We found that a combination of IFNα and anti–PD-1–based …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Enhancing immune cell functions in tumors remains a major challenge in cancer
immunotherapy. Hypoxia is a common feature of solid tumors, and cells adapt by …

Angiogenesis is an essential process involved in various physiological, including
placentation, and pathological, including cancer and endometriosis, processes. Melatonin …

Hypoxia is frequently observed in solid tumors and also one of the major obstacles for
effective cancer therapies. Cancer cells take advantage of their ability to adapt hypoxia to …

A role for hypoxia‐inducible factors (HIFs) in hypoxia‐dependent regulation of tumor cell
metabolism has been thoroughly investigated and covered in reviews. However, there is …

Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

Tissue hypoxia commonly occurs in tumors. Hypoxia-inducible factor (HIF)-1 and HIF-2,
which are essential mediators of cellular response to hypoxia, regulate gene expression for …