Oxidative stress contributes to inflammatory and cellular damage in systemic lupus erythematosus: cellular markers and molecular mechanism

Z Yan, Q Chen, Y Xia - Journal of Inflammation Research, 2023 - Taylor & Francis
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with complex
pathogenesis, the treatment of which relies exclusively on the use of immunosuppressants …

Markers of NETosis in patients with systemic lupus erythematosus and antiphospholipid syndrome

T Reshetnyak, K Nurbaeva, I Ptashnik… - International Journal of …, 2023 - mdpi.com
Neutrophil Extracellular Traps (NETs) have been implicated in systemic lupus
erythematosus (SLE) and antiphospholipid syndrome (APS) pathogenesis. The …

The role of neutrophil extracellular traps (NETs) in the pathogenesis of systemic lupus erythematosus and antiphospholipid syndrome

T Reshetnyak, K Nurbaeva - International Journal of Molecular Sciences, 2023 - mdpi.com
Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two related
autoimmune diseases. In recent years, there has been sufficient evidence to suggest that …

Neutrophil extracellular traps-associated markers are elevated in patients with systemic lupus erythematosus

I Jeremic, O Djuric, M Nikolic, M Vlajnic… - Rheumatology …, 2019 - Springer
Neutrophil extracellular traps (NETs) are the main source of autoantigens in systemic lupus
erythematosus (SLE). The aim of this study was to evaluate the clinical importance of NETs …

Biomarkers in childhood-onset systemic lupus erythematosus

EM Cody, HI Brunner - Rheumatic Disease Clinics, 2022 - rheumatic.theclinics.com
Biomarkers in Childhood-Onset Systemic Lupus Erythematosus - Rheumatic Disease
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Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement

L Liu, K de Leeuw, H van Goor… - Arthritis Research & …, 2024 - Springer
Objectives To investigate the levels of plasma neutrophil extracellular traps (NETs) and free
thiols, the latter reflecting systemic oxidative stress (OS), and to explore the relationship …

Pediatric systemic lupus erythematosus: phagocytic defect and oxidase activity of neutrophils

RK Pilania, A Rawat, J Shandilya, K Arora, A Gupta… - Pediatric …, 2022 - nature.com
Background There are limited data on neutrophil function in pediatric-onset systemic lupus
erythematosus (pSLE) patients. This study aimed to evaluate phagocytosis and oxidase …

[HTML][HTML] Association of neutrophil extracellular trap levels with Raynaud's phenomenon, glomerulonephritis and disease index score in SLE patients from Brazil

ED Auer, VBB Hoch, EB da Silva, YR Zonta… - Immunobiology, 2024 - Elsevier
Neutrophil extracellular traps (NETs) are cell-extruded DNA strands coated with neutrophils'
nuclear proteins and enzymes from cytotoxic granules, produced by NETosis, a cell death …

Cf‐02, a novel benzamide‐linked small molecule, blunts NF‐κB activation and NLRP3 inflammasome assembly and improves acute onset of accelerated and severe …

SR Yang, KF Hua, CY Yang, A Chen… - The FASEB …, 2021 - Wiley Online Library
In the present study, acute onset of severe lupus nephritis was successfully treated in mice
using a new, benzamide‐linked, small molecule that targets immune modulation and the …

中性粒细胞胞外诱捕网与自身免疫病

耿晓柯, 于树祥, 闫建设 - 自然杂志, 2023 - nature.shu.edu.cn
摘要中性粒细胞胞外诱捕网(neutrophil extracellular traps, NETs) 是激活的中性粒细胞,
将去浓缩的核染色质和相关蛋白等释放至胞外而形成的网络结构. NETs 可防止感染. 然而 …