Immunological effects of the PE/PPE family proteins of Mycobacterium tuberculosis and related vaccines

F Guo, J Wei, Y Song, B Li, Z Qian, X Wang… - Frontiers in …, 2023 - frontiersin.org
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis
(Mtb), and its incidence and mortality are increasing. The BCG vaccine was developed in the …

PE_PGRS45 (Rv2615c) protein of Mycobacterium tuberculosis perturbs mitochondria of macrophages

Medha, Priyanka, S Sharma… - Immunology and Cell …, 2023 - Wiley Online Library
The PE_PGRS proteins have coevolved with the antigenic ESX‐V secretory system and are
abundant in pathogenic Mycobacterium. Only a few PE_PGRS proteins have been …

Host and microbial regulation of mitochondrial reactive oxygen species during mycobacterial infections

JK Kim, EK Jo - Mitochondrion, 2024 - Elsevier
Abstract Mycobacteria, including Mycobacterium tuberculosis (Mtb) and non-tuberculous
mycobacteria (NTM), pose challenges in treatment due to their increased resistance to …

A potent subset of Mycobacterium tuberculosis glycoproteins as relevant candidates for vaccine and therapeutic target

S Yari, P Afrough, F Yari, M Ghazanfari Jajin… - Scientific Reports, 2023 - nature.com
Tuberculosis (TB) remains one of the most afflictive bacterial infections globally. In high
burden TB countries, surveillance, diagnosis and treatment of drug resistant TB (RR and …

Late stage specific Rv0109 (PE_PGRS1) protein of Mycobacterium tuberculosis induces mitochondria mediated macrophage apoptosis

P Bhatt, H Joshi, S Sharma, M Sharma - Microbial Pathogenesis, 2023 - Elsevier
Mitochondria are the powerhouse of the cell and a critical cell signalling hub that decides
the fate of the cell. Mycobacterium tuberculosis (Mtb) being a successful pathogen targets …

Mycobacterium tuberculosis protein PPE15 (Rv1039c) possesses eukaryote-like SH3 domain that interferes with NADPH Oxidase assembly and Reactive Oxygen …

S Sharma, H Joshi, C Kumar, R Waseem… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract Inhibition of Reactive Oxygen Species (ROS) is one of the strategies that
Mycobacterium tuberculosis (Mtb) employs as its defence mechanism. In this study, the role …

Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection

A Vu, I Glassman, G Campbell, S Yeganyan… - International Journal of …, 2024 - mdpi.com
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), a prevalent
infectious disease affecting populations worldwide. A classic trait of TB pathology is the …

Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy

L Wei, L Liu, Z Meng, K Qi, X Gao, J Feng, J Luo - Inflammation Research, 2024 - Springer
Background The pathogen responsible for tuberculosis is called Mycobacterium
tuberculosis. Its interaction with macrophages has a significant impact on the onset and …

Role of PE/PPE proteins of Mycobacterium tuberculosis in triad of host mitochondria, oxidative stress and cell death

S Sharma, M Sharma - Microbial Pathogenesis, 2024 - Elsevier
The PE and PPE family proteins of Mycobacterium tuberculosis (Mtb) is exclusively found in
pathogenic Mycobacterium species, comprising approximately 8-10% of the Mtb genome …

Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection

H Ruan, M Lyu, H Lai, L Niu, Z Zhao… - Interdisciplinary …, 2024 - Wiley Online Library
Tuberculosis (TB) is a fatal infectious disease that continues to pose a serious public health
threat. The emergence of drug‐resistant TB has further worsened the burden of the disease …