Targeting ARID1A mutations in cancer
J Mullen, S Kato, JK Sicklick, R Kurzrock - Cancer treatment reviews, 2021 - Elsevier
Genes encoding SWI/SNF chromatin remodeling complex subunits are collectively mutated
in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein …
in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein …
Clear cell carcinoma of the ovary: a clinical and molecular perspective
Clear cell carcinoma of the ovary has distinct biology and clinical behavior. There are
significant geographical and racial differences in the incidence of clear cell carcinoma …
significant geographical and racial differences in the incidence of clear cell carcinoma …
Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers
The gene encoding ARID1A, a chromatin remodeler, shows one of the highest mutation
rates across many cancer types. Notably, ARID1A is mutated in over 50% of ovarian clear …
rates across many cancer types. Notably, ARID1A is mutated in over 50% of ovarian clear …
Endometriosis-associated ovarian carcinomas: how PI3K/AKT/mTOR pathway affects their pathogenesis
TS Driva, C Schatz, J Haybaeck - Biomolecules, 2023 - mdpi.com
Ovarian clear cell (OCCC) and endometrioid (EnOC) carcinomas are often subsumed under
the umbrella term “endometriosis-associated ovarian cancer”(EAOC), since they frequently …
the umbrella term “endometriosis-associated ovarian cancer”(EAOC), since they frequently …
Endometriosis-associated ovarian neoplasia
X Matias-Guiu, CJR Stewart - Pathology, 2018 - Elsevier
This article reviews the most relevant pathological and molecular features of ovarian
tumours that are associated with endometriosis. Endometriosis is a common condition …
tumours that are associated with endometriosis. Endometriosis is a common condition …
Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth
KH Kim, CWM Roberts - Cancer genetics, 2014 - Elsevier
SMARCB1 (INI1/SNF5/BAF47), a core subunit of the SWI/SNF (BAF) chromatin-remodeling
complex, is inactivated in the large majority of rhabdoid tumors, and germline heterozygous …
complex, is inactivated in the large majority of rhabdoid tumors, and germline heterozygous …
[HTML][HTML] Endometriosis-associated ovarian carcinomas: Insights into pathogenesis, diagnostics, and therapeutic targets—A narrative review
EP Samartzis, SI Labidi-Galy, M Moschetta… - Annals of …, 2020 - ncbi.nlm.nih.gov
Endometriosis is a benign gynecologic condition affecting up to one woman out of ten of
reproductive age. It is defined by the presence of endometrial-like tissue in localizations …
reproductive age. It is defined by the presence of endometrial-like tissue in localizations …
[HTML][HTML] Loss of ARID1A expression sensitizes cancer cells to PI3K-and AKT-inhibition
EP Samartzis, K Gutsche, KJ Dedes, D Fink, M Stucki… - Oncotarget, 2014 - ncbi.nlm.nih.gov
ARID1A mutations are observed in various tumors, including ovarian clear cell (OCCC) and
endometrioid carcinomas, endometrial, and breast carcinomas. They commonly result in …
endometrioid carcinomas, endometrial, and breast carcinomas. They commonly result in …
[HTML][HTML] Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma
H Kobayashi, H Sugimoto, S Onishi… - Oncology …, 2015 - spandidos-publications.com
Ovarian clear cell carcinoma can arise from endometriosis; however, it is distinct from other
types of epithelial ovarian carcinoma in terms of its clinicopathological and molecular …
types of epithelial ovarian carcinoma in terms of its clinicopathological and molecular …
Cellular mechanism of gene mutations and potential therapeutic targets in ovarian cancer
T Guo, X Dong, S Xie, L Zhang, P Zeng… - Cancer management …, 2021 - Taylor & Francis
Ovarian cancer is a common and complex malignancy with poor prognostic outcome. Most
women with ovarian cancer are diagnosed with advanced stage disease due to a lack of …
women with ovarian cancer are diagnosed with advanced stage disease due to a lack of …