GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Natural products (NPs) have a long history of clinical use and are rich source of bioactive
compounds. The development of tools and techniques for identifying and analyzing NP …

Light-triggered reversible modulation of physiological functions offers the promise of
enabling on-demand spatiotemporally controlled therapeutic interventions. Optogenetics …

Quantification of the anticholinergic exposure insufficiently or imprecisely incorporates
dosage information, leading to inaccurate estimations. The aim was to construct a novel …

Background Cognitive deficits are prevalent in people with schizophrenia and associated
with functional impairments. In addition to antipsychotics, pharmacotherapy in schizophrenia …

Muscarinic acetylcholine receptors (mAChRs) belong to the superfamily of G-protein-
coupled receptors (GPCRs). The family of mAChRs is composed of five subtypes, M1, M2 …

Introduction: Cholinergic Receptor Muscarinic 1 (CHRM1) is a G protein-coupled
acetylcholine (ACh) receptor predominantly expressed in the cerebral cortex. In a …

The cholinergic hypothesis has been reported first being the cause of memory dysfunction in
the Alzheimer's disease. Researchers around the globe have focused their attention on …

Glioblastomas (GBM) are the most aggressive form of primary brain tumors in humans. A key
feature of malignant gliomas is their cellular heterogeneity. In particular, the presence of an …

The involvement of muscarinic receptors in cancer has been reported. Recently we have
demonstrated that the activation of M2 muscarinic receptors, through arecaidine propargyl …