The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

Highly ordered organisation of striated muscle is the prerequisite for the fast and
unidirectional development of force and motion during heart and skeletal muscle …

Congestive heart failure (CHF) can result from various disease states with inadequate
cardiac output. CHF due to dilated cardiomyopathy (DCM) is a familial disease in 20–30% of …

The 364 exon TTN gene encodes titin (TTN), the largest known protein, which plays key
structural, developmental, mechanical, and regulatory roles in cardiac and skeletal muscles …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Tibial muscular dystrophy (TMD) is an autosomal dominant late-onset distal myopathy linked
to chromosome 2q31. The linked region includes the giant TTN gene, which encodes the …

The spectrin superfamily of proteins plays key roles in assembling the actin cytoskeleton in
various cell types, crosslinks actin filaments, and acts as scaffolds for the assembly of large …

Like the ancient Greek hero Hercules, striated muscle is famous for performing impressive
feats of strength. The procurement of food, breathing, and defense or escape from harm all …

Developmental changes in contractile behavior are known to occur during fetal and
postnatal heart development. In this study, we examined whether adaptations take place in …

The Z-disc, appearing as a fine dense line forming sarcomere boundaries in striated
muscles, when studied in detail reveals crosslinked filament arrays that transmit tension and …