Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

Nature's pharmacy has undoubtedly served humans as an affordable and safer health-care
regime for a long times. Cardamonin, a chalconoid present in several plants has been …

Rheumatoid arthritis (RA), a chronic autoimmune disease (AD), can cause irreversible loss
of joint function. The methotrexate (MTX) is the first-line choice in the treatment of RA; …

Extracts from Taiwan's traditional medicinal mushroom, Antrodia cinnamomea, exhibit anti-
inflammatory activities in cellular and preclinical studies. However, this paper is the first to …

Hemophilic arthropathy is a form of joint disease that develops secondary to joint bleeding
and presents with synovial hypertrophy, cartilage and bony destruction. The arthropathy can …

Objective During rheumatoid arthritis (RA), the angiogenic processes, occurring with pannus-
formation, may be a therapeutic target. JAK/STAT-pathway may play a role and the aim of …

Hypoxia is an important micro-environmental characteristic of rheumatoid arthritis (RA).
Hypoxia-inducible factors (HIF) are key transcriptional factors that are highly expressed in …

Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease that selectively
attacks human joints. The common non-targeted treatment approaches lead to obvious side …

Angiogenesis is the formation of new capillaries from preexisting vasculature. The
perpetuation of angiogenesis plays a critical role in the pathogenesis of various disease …

Rheumatoid arthritis (RA) is a chronic multifactorial disease, provocative, and degenerative
autoimmune condition that impacts millions of individuals around the globe. As a result of …