PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

Diabetic neuropathies (DNs) differ in clinical course, distribution, fiber involvement (type and
size), and pathophysiology, the most typical type being a length-dependent distal symmetric …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

In recent decades, oxidative stress has become a focus of interest in most biomedical
disciplines and many types of clinical research. Increasing evidence shows that oxidative …

Diabetic autonomic neuropathy (DAN) is a serious and common complication of diabetes.
Despite its relationship to an increased risk of cardiovascular mortality and its association …

Diabetes mellitus increases the risk of heart failure independently of underlying coronary
artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying …

Context: Diabetic complications appear to be multifactorial in origin, but in particular, the
biochemical process of advanced glycation, which is accelerated in diabetes as a result of …

Neuropathy is the most common and debilitating complication of diabetes and results in
pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of …

Objectives: In this study, we have investigated the effects of cannabidiol (CBD) on
myocardial dysfunction, inflammation, oxidative/nitrative stress, cell death, and interrelated …