Significant advances in materials, microscale technology, and stem cell biology have
enabled the construction of 3D tissues and organs, which will ultimately lead to more …

The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

Reconstruction of skin equivalents with physiologically relevant cellular and matrix
architecture is indispensable for basic research and industrial applications. As skin-nerve …

Three-dimensional (3D) in vitro models capturing both the structural and dynamic complexity
of the in vivo situation are in great demand as an alternative to animal models. Despite …

Abstract Blood-Brain Barrier (BBB) acts as a highly impermeable barrier, presenting an
impediment to the crossing of most classical drugs targeted for neurodegenerative diseases …

Oral mucositis (OM) is a debilitating complication affecting roughly 70% of head and neck
cancer patients receiving chemotherapy and/or radiation treatment. No broadly effective …

Viral and bacterial infections continue to pose significant challenges for numerous
individuals globally. To develop novel therapies to combat infections, more insight into the …

Background: The epithelial layer of the nasal mucosa is the first barrier for drug permeation
during intranasal drug delivery. With increasing interest for intranasal pathways, adequate in …

The human oral mucosa hosts a diverse microbiome and is exposed to potentially toxic
biomaterials from dental restoratives. Mucosal health is partly determined by cell and tissue …

Patients with cystic fibrosis (CF) experience severe lung disease, including persistent
infections, inflammation, and irreversible fibrotic remodeling of the airways. Although therapy …