Biomarker-driven molecular imaging probes in radiotherapy

H Li, Q Gong, K Luo - Theranostics, 2024 - pmc.ncbi.nlm.nih.gov
Background: Biomarker-driven molecular imaging has emerged as an integral part of cancer
precision radiotherapy. The use of molecular imaging probes, including nanoprobes, have …

Radiation-induced senescence in glioblastoma: An overview of the mechanisms and eradication strategies

N Dehghan, SN Mousavikia, Y Qasempour, H Azimian - Life Sciences, 2024 - Elsevier
Radiotherapy as a treatment method for glioblastoma is limited due to the intrinsic apoptosis
resistance mechanisms of the tumor. Administration of higher radiation doses contributes to …

Implantable Microneedle‐Mediated Eradication of Postoperative Tumor Foci Mitigates Glioblastoma Relapse

Y Zhang, Z Fang, Z Liu, K Xi, Y Zhang… - Advanced …, 2024 - Wiley Online Library
Glioblastoma multiforme (GBM) remains incurable despite multimodal treatments after
surgical debulking. Almost all patients with GBM relapse within a narrow margin (2–3 cm) of …

Stimulation of tumoricidal immunity via bacteriotherapy inhibits glioblastoma relapse

Y Zhang, K Xi, Z Fu, Y Zhang, B Cheng, F Feng… - Nature …, 2024 - nature.com
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by invasive
behavior and a compromised immune response, presenting treatment challenges. Surgical …

Radiotherapy‐Induced Astrocyte Senescence Promotes an Immunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth

J Ji, K Ding, B Cheng, X Zhang, T Luo… - Advanced …, 2024 - Wiley Online Library
Accumulating evidence suggests that changes in the tumor microenvironment caused by
radiotherapy are closely related to the recurrence of glioma. However, the mechanisms by …

[HTML][HTML] HDAC7 drives glioblastoma to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages

S Zhao, R Zhao, C Wang, C Ma, Z Gao, B Li, Y Qi… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: Glioblastoma multiforme (GBM) is an aggressive brain tumour for which current
traditional treatment approaches have been unsuccessful, owing to the high genetic …

Involvement of Cyclooxygenase-2 in Establishing an Immunosuppressive Microenvironment in Tumorspheres Derived from TMZ-Resistant Glioblastoma Cell Lines …

F Lombardi, FR Augello, S Artone, A Ciafarone, S Topi… - Cells, 2024 - mdpi.com
Glioblastoma (GBM) is characterized by an immunosuppressive tumor microenvironment
(TME) strictly associated with therapy resistance. Cyclooxygenase-2 (COX-2) fuels GBM …

Mechanism of Notch Signaling Pathway in Malignant Progression of Glioblastoma and Targeted Therapy

S Wang, S Gu, J Chen, Z Yuan, P Liang, H Cui - Biomolecules, 2024 - mdpi.com
Glioblastoma multiforme (GBM) is the most aggressive form of glioma and the most common
primary tumor of the central nervous system. Despite significant advances in clinical …

A new perspective on prostate cancer treatment: the interplay between cellular senescence and treatment resistance

MY Xu, ZY Xia, JX Sun, CQ Liu, Y An, JZ Xu… - Frontiers in …, 2024 - frontiersin.org
The emergence of resistance to prostate cancer (PCa) treatment, particularly to androgen
deprivation therapy (ADT), has posed a significant challenge in the field of PCa …

Glycemia and Coagulation in Patients with Glioblastomas

D Orešković, AM Pohlen, I Cvitković, JF Alen… - World neurosurgery, 2024 - Elsevier
Background Glioblastomas are among the most malignant tumors which, despite aggressive
treatment, currently have an abysmal prognosis. These lesions are known to cause local …