Recent genetic studies have revealed shared immunological mechanisms in several
immune-related disorders that further our understanding of the development and …

The diagnosis of inflammatory bowel disease (IBD) with its 2 main subforms, Crohn's
disease and ulcerative colitis, is based on clinical, endoscopic, radiologic, and histologic …

Patients with membranous nephropathy have an increased risk of malignancy compared to
the general population, but the target antigen for malignancy-associated membranous …

Inflammatory bowel disease (IBD) has been attributed to aberrant mucosal immunity to the
intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic …

Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract
with a complex genetic and environmental etiology. In an effort to identify genetic variation …

Background Interleukin (IL)-17F, produced in IL-23R-expressing Th17 cells, is a novel
member of the IL-17 cytokine family. Given the association of IL23R with inflammatory bowel …

Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we
investigated 50 previously reported susceptibility loci in a German sample of individuals with …

Technological advances in the large scale analysis of human genetics have generated
profound insights into possible genetic contributions to chronic diseases including the …

Background We analyzed the influence of Crohn's disease (CD)-associated IL23R gene
variants on IL-22 that is expressed in IL-23R+ Th17 cells. Methods IL-22 serum levels were …

Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal
microbiota with the host immune system in genetically susceptible individuals. The largest …