PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma
Protein kinase C (PKC) is activated downstream of gain-of-function GNAQ or GNA11
(GNAQ/GNA11) mutations in over 90% of uveal melanoma (UM). Phase I clinical trials of …
(GNAQ/GNA11) mutations in over 90% of uveal melanoma (UM). Phase I clinical trials of …
[PDF][PDF] A review on unexploited features of n-dimensional BIM: An Indian construction scenario.
R Sood, B Laishram - 2022 - ciobwcs.com
Infrastructure sector is a backbone of economic development for most of the countries
worldwide. Indian AEC (Architecture, Engineering and Construction) industry is one of the …
worldwide. Indian AEC (Architecture, Engineering and Construction) industry is one of the …
The BET inhibitor JQ1 suppresses tumor survival by ABCB5-mediated autophagy in uveal melanoma
W Liu, Z Cui, Q Wan, Y Liu, M Chen, Y Cheng, X Sang… - Cellular …, 2025 - Elsevier
Uveal melanoma (UM), the most common adult ocular tumor, is aggressive and resistant to
treatment, posing threat to patients' lives. The novel, effective therapies and the exploration …
treatment, posing threat to patients' lives. The novel, effective therapies and the exploration …
Reversing vemurafenib‐resistance in primary melanoma cells by combined romidepsin and type I IFN treatment through blocking of tumorigenic signals and induction …
A Fragale, E Stellacci, G Romagnoli… - … Journal of Cancer, 2023 - Wiley Online Library
BRAFV600 mutations are the most common oncogenic alterations in melanoma cells,
supporting proliferation, invasion, metastasis and immune evasion. In patients, these …
supporting proliferation, invasion, metastasis and immune evasion. In patients, these …
[HTML][HTML] Specific human endogenous retroviruses predict metastatic potential in uveal melanoma
Uveal melanoma (UM) is a unique disease in that patients with primary UM are well stratified
based on their risk of developing metastasis, yet there are limited effective treatments once …
based on their risk of developing metastasis, yet there are limited effective treatments once …
Genetically encoded fluorescent sensors for visualizing polyamine levels, uptake, and distribution
R Tamura, J Chen, M De Jaeger, JF Morris, DA Scott… - …, 2024 - pmc.ncbi.nlm.nih.gov
Polyamines are abundant and physiologically essential biomolecules that play a role in
numerous processes, but are disrupted in diseases such as cancer, and cardiovascular and …
numerous processes, but are disrupted in diseases such as cancer, and cardiovascular and …
PI3K/mTOR dual inhibitor pictilisib stably binds to site I of human serum albumin as observed by computer simulation, multispectroscopic, and microscopic studies
H Yang, Y Ma, H Zhang, J Ma - Molecules, 2022 - mdpi.com
Pictilisib (GDC-0941) is a well-known dual inhibitor of class I PI3K and mTOR and is
presently undergoing phase 2 clinical trials for cancer treatment. The present work …
presently undergoing phase 2 clinical trials for cancer treatment. The present work …