Animal models as a tool in hepatocellular carcinoma research: A Review

NP Santos, AA Colaco, PA Oliveira - Tumor Biology, 2017 - journals.sagepub.com
Cancer is the first cause of death in developed countries and the second in developing
countries. Concerning the most frequent worldwide-diagnosed cancer, primary liver cancer …

An overview of natural plant products in the treatment of hepatocellular carcinoma

D Rawat, S Shrivastava, RA Naik… - Anti-Cancer Agents …, 2018 - ingentaconnect.com
Background: Liver cancer is the fifth most commonly diagnosed cancer and the second
leading cause of cancer-related deaths worldwide. Among the liver cancers, hepatocellular …

6‐Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine‐Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti‐Inflammatory …

MA Alsahli, SA Almatroodi, A Almatroudi… - Mediators of …, 2021 - Wiley Online Library
Diethylnitrosamine (DEN) is a well‐known hepatocarcinogen, and its oral administration
causes severe liver damage including cancer. DEN induces the pathogenesis of the liver …

[HTML][HTML] Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met …

NYS Yassin, SF AbouZid, AM El-Kalaawy, TM Ali… - Biomedicine & …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) has been identified as one of the most deadly
malignancies with limited therapeutic efficacy worldwide. However, understanding the …

[HTML][HTML] TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

A Esparza-Baquer, I Labiano, O Sharif, A Agirre-Lizaso… - Gut, 2021 - gut.bmj.com
Objective Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually
arising on a background of chronic liver injury involving inflammatory and hepatic …

Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine

Y Ding, Z Wu, Y Wei, L Shu, Y Peng - Journal of Cancer Research and …, 2017 - Springer
Purpose Hepatocellular carcinoma (HCC) cases are closely associated with chronic
inflammation and fibrosis which is known as hepatic inflammation-fibrosis-cancer (IFC) axis …

[HTML][HTML] Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug …

S Saber, M Nasr, AS Saad, AAE Mourad… - Biomedicine & …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. It
was suggested that albendazole (ABZ) is a powerful inhibitor of several carcinoma types …

Cerium oxide nanoparticles attenuate oxidative stress and inflammation in the liver of diethylnitrosamine-treated mice

OA Adebayo, O Akinloye, OA Adaramoye - Biological trace element …, 2020 - Springer
The catalytic activity of cerium oxide nanoparticles (CeO2NPs) is responsible for its
application as an antitumor agent. This activity may be due to its ability to switch between III …

Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal …

N Kishida, S Matsuda, O Itano, M Shinoda… - BMC …, 2016 - Springer
Background The incidence of hepatocellular carcinoma with nonalcoholic steatohepatitis is
increasing, and its clinicopathological features are well established. Several animal models …

Proteomic research on the antitumor properties of medicinal mushrooms

B Jakopovic, N Oršolić, I Jakopovich - Molecules, 2021 - mdpi.com
Medicinal mushrooms are increasingly being recognized as an important therapeutic
modality in complementary oncology. Until now, more than 800 mushroom species have …