Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their
prosperous gene regulation capability. The efficacy of DNAzymes against many types of …

The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Accumulating evidence indicatesthat programmed necrosis plays a critical role in cell death
during ischemia–reperfusion. Necrostatin-1 (Nec-1), a small molecule capable of inhibiting a …

Diabetes is characterized by hyperglycemia, loss of functional islet beta cell mass,
deficiency of glucose-lowering insulin, and persistent alpha cell secretion of gluconeogenic …

Pancreatic β-cells are responsible for insulin production, and loss of functional β-cell mass is
now recognized as a critical step in the pathogenesis of both type 1 and type 2 diabetes …

Intravenous vitamin D is standard therapy for secondary hyperparathyroidism in
hemodialysis (HD) patients. In for-profit dialysis clinics, mortality was higher for patients on …

Significance: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D
upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by …

Vitamin D deficiency is common among patients with myocardial diseases because sun‐
induced vitamin D production in the skin and dietary intake of vitamin D is often insufficient …

Aims We investigated whether glucose fluctuations aggravate cardiac fibrosis and increase
the occurrence of atrial fibrillation (AF) in rats with diabetes mellitus (DM). Methods and …

Classic therapeutics for ischemic heart disease are less effective in individuals with the
metabolic syndrome. As the prevalence of the metabolic syndrome is increasing, better …