Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Breaking down the cell wall: Still an attractive antibacterial strategy

J Zhou, Y Cai, Y Liu, H An, K Deng, MA Ashraf… - Frontiers in …, 2022 - frontiersin.org
Since the advent of penicillin, humans have known about and explored the phenomenon of
bacterial inhibition via antibiotics. However, with changes in the global environment and the …

Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms

KA Lacey, L Serpas, S Makita, Y Wang… - Journal of Experimental …, 2023 - rupress.org
Extracellular DNase DNASE1L3 maintains tolerance to self-DNA in humans and mice,
whereas the role of its homolog DNASE1 remains controversial, and the overall function of …

Impaired respiration elicits SrrAB-dependent programmed cell lysis and biofilm formation in Staphylococcus aureus

AA Mashruwala, A Guchte, JM Boyd - Elife, 2017 - elifesciences.org
Biofilms are communities of microorganisms attached to a surface or each other. Biofilm-
associated cells are the etiologic agents of recurrent Staphylococcus aureus infections …

Wall teichoic acids mediate increased virulence in Staphylococcus aureus

S Wanner, J Schade, D Keinhörster, N Weller… - Nature …, 2017 - nature.com
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are the
cause of a severe pandemic consisting primarily of skin and soft tissue infections. The …

[PDF][PDF] Guidelines for the successful generation of protein–ligand complex crystals

I Müller - Acta Crystallographica Section D: Structural Biology, 2017 - journals.iucr.org
With continuous technical improvements at synchrotron facilities, data-collection rates have
increased dramatically. This makes it possible to collect diffraction data for hundreds of …

Dual-targeting small-molecule inhibitors of the Staphylococcus aureus FMN riboswitch disrupt riboflavin homeostasis in an infectious setting

H Wang, PA Mann, L Xiao, C Gill, AM Galgoci… - Cell chemical …, 2017 - cell.com
Riboswitches are bacterial-specific, broadly conserved, non-coding RNA structural elements
that control gene expression of numerous metabolic pathways and transport functions …

Enzyme structures of the bacterial peptidoglycan and wall teichoic acid biogenesis pathways

NA Caveney, FKK Li, NCJ Strynadka - Current opinion in structural biology, 2018 - Elsevier
The bacterial cell wall is a complex polymeric structure with essential roles in defence,
survival and pathogenesis. Common to both Gram-positive and Gram-negative bacteria is …

Multidrug intrinsic resistance factors in Staphylococcus aureus identified by profiling fitness within high-diversity transposon libraries

M Rajagopal, MJ Martin, M Santiago, W Lee, VN Kos… - MBio, 2016 - Am Soc Microbiol
Staphylococcus aureus is a leading cause of life-threatening infections worldwide. The MIC
of an antibiotic against S. aureus, as well as other microbes, is determined by the affinity of …

A review of pyridine and pyrimidine derivatives as anti-MRSA agents

A Kumar, AK Singh, S Thareja, P Kumar - Anti-Infective Agents, 2023 - ingentaconnect.com
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a Gram-positive strain
whose resistance against existing antibiotics is a significant concern for researchers across …