Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

Peptides can act as targeting molecules, analogously to oligonucleotide aptamers and
antibodies. They are particularly efficient in terms of production and stability in physiological …

The appearance and rapid spread of drug resistant strains of tuberculosis (TB), one of the
deadliest infectious diseases, pose a serious threat to public health and increase the need …

Most therapeutic agents used for treating brain malignancies face hindered transport
through the blood–brain barrier (BBB) and poor tissue penetration. To overcome these …

Reflecting the known biological activity of isoniazid-based hydrazones, seventeen
hydrazones of 4-(trifluoromethyl) benzohydrazide as their bioisosters were synthesized from …

A systematic study on sulfonamide derivatives with salicylamide core is presented for
possible use in pharmaceutical applications. The molecular structure of eight different …

Peptide–drug conjugates are organic molecules composed of (i) a small drug molecule,(ii) a
peptide and (iii) a linker. The drug molecule is mandatory for the biological action, however …

The reaction of 3-oxo-2-arylhydrazonopropanals with acetoacetanilide in an equimolar ratio,
under DBU/1, 4-dioxane/microwave irradiation reaction conditions, resulted in …

Mycobacterium tuberculosis is an intracellular pathogen and the uptake of the
antimycobacterial compounds by host cells is limited. Novel antimycobacterials effective …

Tuberculosis (TB) is among the greatest public health and safety concerns in the 21st
century Mycobacterium tuberculosis, which causes TB, infects alveolar macrophages and …