Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

Metal exposure is pervasive and not limited to sporadic poisoning events or toxic waste
sites. Hundreds of millions of people around the globe are affected by chronic metal …

SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 recepto... : PAIN SARS-CoV-2 spike
protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia : PAIN …

The immense majority of genes are alternatively spliced and there are many isoforms
specifically associated with cancer progression and metastasis. The splicing pattern of …

Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

Infection by bacteria, viruses, and parasites may lead to fetal death, organ injury, or limited
sequelae depending on the pathogen. Here, we consider the role of infection during …

The arteriovenous fistula has been used for more than 50 years to provide vascular access
for patients undergoing hemodialysis. More than 1.5 million patients worldwide have end …

The physiology of microvessels limits the growth and development of tumours. Tumours gain
nutrients and excrete waste through growth-associated microvessels. New anticancer …

The concept of antiangiogenic therapy in cancer treatment has led to the approval of
different agents, most of them targeting the well known vascular endothelial growth factor …