We review the recent developments in understanding the bacterial chemotaxis signaling
pathway by using quantitative modeling methods. The models developed are based on …

Bacterial chemotaxis represents one of the simplest and best studied examples of
unicellular behavior. Chemotaxis allows swimming bacterial cells to follow chemical …

Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics
for undergraduate or graduate students. It maps the huge and complex landscape of cell …

Managing the overwhelming numbers of molecular states and interactions is a fundamental
obstacle to building predictive models of biological systems. Here we introduce the Network …

Molecular binding is an interaction between molecules that results in a stable association
between those molecules. Cooperative binding occurs if the number of binding sites of a …

In their natural environment, cells need to extract useful information from complex temporal
signals that vary over a wide range of intensities and time scales. Here, we study how such …

We studied the response of swimming Escherichia coli (E. coli) bacteria in a comprehensive
set of well-controlled chemical concentration gradients using a newly developed microfluidic …

The Escherichia coli chemotaxis‐signaling pathway computes time derivatives of
chemoeffector concentrations. This network features modules for signal …

Regular environmental conditions allow for the evolution of specifically adapted responses,
whereas complex environments usually lead to conflicting requirements upon the …

Many types of cells are able to accurately sense shallow gradients of chemicals across their
diameters, allowing the cells to move toward or away from chemical sources. This …