Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Here we describe a detailed protocol for both data collection and interpretation with respect
to ion mobility–mass spectrometry analysis of large protein assemblies. Ion mobility is a …

The small multidrug resistance (SMR) protein family is a bacterial multidrug transporter
family. As suggested by their title, SMR proteins are composed of four transmembrane α …

The ability to maintain interactions between soluble protein subunits in the gas phase of a
mass spectrometer gives critical insight into the stoichiometry and interaction networks of …

The fact that ions of macromolecular complexes produced by electrospray ionization can be
maintained intact in a mass spectrometer has stimulated exciting new lines of research. In …

Proteins and the complexes they form with their ligands are the players of cellular action.
Their function is directly linked with their structure making the structural analysis of protein …

Over the past two decades, mass spectrometry (MS) of protein complexes from their native
state has made inroads into structural biology. To coincide with the 20 th anniversary of …

The application of mass spectrometry (MS) to the study of progressively larger and more
complex macromolecular assemblies is proving increasingly useful for structural biologists …

Mass spectrometry (MS) is a powerful tool for determining the mass of biomolecules with
high accuracy and sensitivity. MS performed under so‐called “native conditions”(native MS) …