Autophagy is a cellular process involved in the selective degradation and recycling of
dysfunctional intracellular components. It plays a crucial role in maintaining cellular …

The activating molecule in Beclin-1-regulated autophagy (Ambra1), also known as
autophagy/Beclin-1 regulator 1, is a highly intrinsically disordered and vertebrate-conserved …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Optimal autophagic activity is crucial to maintain muscle integrity, with either reduced or
excessive levels leading to specific myopathies. LGMD2H is a muscle dystrophy caused by …

Background Maintaining healthy mitochondria is mandatory for muscle viability and function.
An essential surveillance mechanism targeting defective and harmful mitochondria to …

Autophagy is an evolutionarily conserved catabolic process which allows lysosomal
degradation of complex cytoplasmic components into basic biomolecules that are recycled …

Autophagy is a constitutive pathway that allows the lysosomal degradation of damaged
components. This conserved process is essential for metabolic plasticity and tissue …

AMBRA1 is a crucial factor for nervous system development, and its function has been
mainly associated with autophagy. It has been also linked to cell proliferation control …

Autophagy-mediated degradation of mitochondria (mitophagy) is a key process in cellular
quality control. Although mitophagy impairment is involved in several patho-physiological …

From a hitherto underappreciated phenomenon, autophagy has become one of the most
intensively studied cellular processes in recent years. Its role in cellular homeostasis …