Pseudomonas Exotoxin A: optimized by evolution for effective killing

M Michalska, P Wolf - Frontiers in microbiology, 2015 - frontiersin.org
Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium
Pseudomonas aeruginosa. This review describes current knowledge about the intoxication …

Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

M Sainz-Mejías, I Jurado-Martín, S McClean - Cells, 2020 - mdpi.com
Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with
cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and …

Progress Toward the Elusive Pseudomonas aeruginosa Vaccine

C Merakou, MM Schaefers, GP Priebe - Surgical infections, 2018 - liebertpub.com
Background: The gram-negative bacterial pathogen Pseudomonas aeruginosa causes a
wide range of infections, mostly in hospitalized and immunocompromised patients, those …

Designs of antigen structure and composition for improved protein-based vaccine efficacy

K Saylor, F Gillam, T Lohneis, C Zhang - Frontiers in immunology, 2020 - frontiersin.org
Today, vaccinologists have come to understand that the hallmark of any protective immune
response is the antigen. However, it is not the whole antigen that dictates the immune …

Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa

A Hoggarth, A Weaver, Q Pu, T Huang… - Drug design …, 2019 - Taylor & Francis
Vaccines for Pseudomonas aeruginosa have been of longstanding interest to
immunologists, bacteriologists, and clinicians, due to the widespread prevalence of hospital …

Vaccination to Prevent Pseudomonas aeruginosa Bloodstream Infections

RJ Hart, LA Morici - Frontiers in Microbiology, 2022 - frontiersin.org
The bacterium Pseudomonas aeruginosa (Pa) is ubiquitous in the environment and causes
opportunistic infections in humans. Pa is increasingly becoming one of the most difficult to …

Immunoinformatics design of multivalent chimeric vaccine for modulation of the immune system in Pseudomonas aeruginosa infection

S Aminnezhad, A Abdi-Ali, T Ghazanfari… - Infection, Genetics and …, 2020 - Elsevier
Increasing in drug-resistant Pseudomonas aeruginosa and high mortality and morbidity rate
have become a health challenge worldwide; therefore, developing the novel therapeutic …

Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia

B Behrouz, FB Hashemi, MJ Fatemi… - Journal of …, 2017 - Wiley Online Library
Pseudomonas aeruginosa lung infections present a major challenge to healthcare systems
worldwide because they are commonly associated with high morbidity and mortality. Here …

Immunological Properties of Exotoxin A Toxoid-Detoxified Lipopolysaccharide-Gold Nanoparticles Conjugate Against Pseudomonas aeruginosa Infection

F Najafzadeh, A Tanomand, A Hadadi… - Iranian Journal of …, 2021 - iji.sums.ac.ir
Background: Pseudomonas aeruginosa is an important opportunistic pathogen, especially
in patients with compromised host defense. Objective: To prepare the conjugate of detoxified …

Перспективные направления использования препаратов на основе рекомбинантного флагеллина

ГА Софронов, ЕВ Мурзина, ВН Болехан… - Медицинский …, 2017 - elibrary.ru
В статье представлены результаты анализа современной научной литературы,
посвященной изучению биологической активности бактериального белка флагеллина с …