P-type ATPases: Many more enigmas left to solve

M Palmgren - Journal of Biological Chemistry, 2023 - ASBMB
P-type ATPases constitute a large ancient super-family of primary active pumps that have
diverse substrate specificities ranging from H+ to phospholipids. The significance of these …

Substrates of P4‐ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine)

HW Shin, H Takatsu - The FASEB Journal, 2019 - Wiley Online Library
ABSTRACT P4‐ATPases, a subfamily of P‐type ATPases, were initially identified as
aminophospholipid translocases in eukaryotic membranes. These proteins generate and …

Structure and autoregulation of a P4-ATPase lipid flippase

M Timcenko, JA Lyons, D Januliene, JJ Ulstrup… - Nature, 2019 - nature.com
Abstract Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active
transport of phospholipids from exoplasmic or luminal leaflets to cytosolic leaflets of …

Arabidopsis flippases cooperate with ARF GTPase exchange factors to regulate the trafficking and polarity of PIN auxin transporters

X Zhang, M Adamowski, P Marhava, S Tan… - The Plant …, 2020 - academic.oup.com
Cell polarity is a fundamental feature of all multicellular organisms. PIN auxin transporters
are important cell polarity markers that play crucial roles in a plethora of developmental …

Crystal structure of a human plasma membrane phospholipid flippase

H Nakanishi, K Irie, K Segawa, K Hasegawa… - Journal of Biological …, 2020 - ASBMB
ATP11C, a member of the P4-ATPase flippase, translocates phosphatidylserine from the
outer to the inner plasma membrane leaflet, and maintains the asymmetric distribution of …

[HTML][HTML] On the track of the lipid transport pathway of the phospholipid flippase ATP8A2-Mutation analysis of residues of the transmembrane segments M1, M2, M3 and …

LS Mogensen, SA Mikkelsen… - … et Biophysica Acta (BBA …, 2024 - Elsevier
P4-ATPases, also known as flippases, translocate specific lipids from the exoplasmic leaflet
to the cytoplasmic leaflet of biological membranes, thereby generating an asymmetric lipid …

[HTML][HTML] Evolution and a revised nomenclature of P4 ATPases, a eukaryotic family of lipid flippases

M Palmgren, JT Østerberg, SJ Nintemann… - … et Biophysica Acta (BBA …, 2019 - Elsevier
In all eukaryotic cells, P4 ATPases, also named phospholipid flippases, generate
phospholipid asymmetry across biological membranes. This process is essential for cell …

The transport mechanism of P4 ATPase lipid flippases

RL López-Marqués, P Gourdon… - Biochemical …, 2020 - portlandpress.com
P4 ATPase lipid flippases are ATP-driven transporters that translocate specific lipids from
the exoplasmic to the cytosolic leaflet of biological membranes, thus establishing a lipid …

The role of secreted proteins in efferocytosis

G Hou, X Wang, A Wang, L Yuan, Q Zheng… - Frontiers in Cell and …, 2024 - frontiersin.org
The clearance of apoptotic cells known as efferocytosis is the final stage of apoptosis, and
includes the recognition, phagocytosis, and degradation of apoptotic cells. The maintenance …

[PDF][PDF] Kinetic modeling of the pyrolysis of propylene glycol

C Al Gemayel, E Honein, A El-Hellani, R Salman… - 2022 - scholarworks.aub.edu.lb
A kinetic model was developed to predict product evolution during the thermal degradation
of propylene glycol (PG) under N2 atmosphere. Main aldehydes that form from PG pyrolysis …