Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

The plant Cannabis sativa contains cannabinoids represented by Δ 9-tetrahydrocannabinol,
which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 …

Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the
inner leaflet of the plasma membrane in neural tissues. PS is synthesized from …

Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

Abstract ANANDAMIDE (N-arachidonoyl-ethanolamine) was recently identified as a brain
arachidonate derivative that binds to and activates cannabinoid receptors1–4, yet the …

Glycerol-based ether lipids including ether phospholipids form a specialized branch of lipids
that in mammals require peroxisomes for their biosynthesis. They are major components of …

Neural membranes contain several classes of glycerophospholipids which turnover at
different rates with respect to their structure and localization in different cells and …

Over one hundred different phospholipid molecular species are known to be present in
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …

Nerve growth factor (NGF) is largely known as a target-derived factor responsible for the
survival and maintenance of the phenotype of specific subsets of peripheral neurones and …

The background knowledge leading to the isolation and identification of anandamide and 2-
arachidonoyl glycerol, the principal endocannabinoids is described. The structure–activity …