Guanosine is a purine nucleoside with important functions in cell metabolism and a
protective role in response to degenerative diseases or injury. The past decade has seen …

The pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease, is a
subject of increasing interest. Loss-of-function mutations in nucleotide‑binding …

Mitochondrial perturbation and oxidative stress are key factors in neuronal vulnerability in
several neurodegenerative diseases or during brain ischemia. Here we have investigated …

Glial cells are involved in multiple cerebral functions that profoundly influence brain tissue
viability during ischemia, and astrocytes are the main source of extracellular purines as …

Guanosine (GUO) is an endogenous modulator of glutamatergic excitotoxicity and has been
shown to promote neuroprotection in in vivo and in vitro models of neurotoxicity. This study …

The function of guanine-based purines (GBPs) is mostly attributed to the intracellular
modulation of heteromeric and monomeric G proteins. However, extracellular effects of …

Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …

Accumulating evidences indicate that endogenous modulators of excitatory synapses in the
mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed …

In the present review, we stress the importance of the purine nucleosides, adenosine and
guanosine, in protecting the nervous system, both centrally and peripherally, via activation of …

The ketamine's potential for the treatment of refractory depression and anxiety has been
considered one the most important discoveries in the last years, however, repeated use of …