Epstein–Barr virus latent genes

MS Kang, E Kieff - Experimental & molecular medicine, 2015 - nature.com
Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

EBV-associated diseases: Current therapeutics and emerging technologies

S Chakravorty, B Afzali, M Kazemian - Frontiers in Immunology, 2022 - frontiersin.org
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …

Spectrum of Epstein-Barr virus–associated diseases

JL Kutok, F Wang - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
The association between Epstein-Barr virus (EBV) and a large number of benign and
malignant diseases is unique among DNA viruses. Within infected tissues, proteins that are …

[HTML][HTML] Viruses associated with human cancer

ME McLaughlin-Drubin, K Munger - … Acta (BBA)-Molecular Basis of Disease, 2008 - Elsevier
It is estimated that viral infections contribute to 15–20% of all human cancers. As obligatory
intracellular parasites, viruses encode proteins that reprogram host cellular signaling …

Epstein–Barr virus in the pathogenesis of NPC

N Raab-Traub - Seminars in cancer biology, 2002 - Elsevier
Epstein–Barr virus (EBV) is consistently detected in nasopharyngeal carcinoma (NPC) from
regions of high and low incidence. EBV DNA within the tumor is homogeneous with regard …

Viral latency and its regulation: lessons from the γ-herpesviruses

SH Speck, D Ganem - Cell host & microbe, 2010 - cell.com
Latency is a state of cryptic viral infection associated with genomic persistence and highly
restricted gene expression. Its hallmark is reversibility: under appropriate circumstances …

Epstein–Barr virus and virus human protein interaction maps

MA Calderwood, K Venkatesan… - Proceedings of the …, 2007 - National Acad Sciences
A comprehensive mapping of interactions among Epstein–Barr virus (EBV) proteins and
interactions of EBV proteins with human proteins should provide specific hypotheses and a …

Pathogenesis and host control of gammaherpesviruses: lessons from the mouse

E Barton, P Mandal, SH Speck - Annual review of immunology, 2011 - annualreviews.org
Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …

BRCA1 is a component of the RNA polymerase II holoenzyme

R Scully, SF Anderson, DM Chao… - Proceedings of the …, 1997 - National Acad Sciences
The familial breast–ovarian tumor suppressor gene product BRCA1 was found to be a
component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to …

Cancers associated with human gammaherpesviruses

KW Wen, L Wang, JR Menke, B Damania - The FEBS journal, 2022 - Wiley Online Library
Epstein–Barr virus (EBV; human herpesvirus 4; HHV‐4) and Kaposi sarcoma‐associated
herpesvirus (KSHV; human herpesvirus 8; HHV‐8) are human gammaherpesviruses that …