Advances in acute ischemic stroke therapy

Y Xiong, AK Wakhloo, M Fisher - Circulation research, 2022 - Am Heart Assoc
The treatment of acute ischemic stroke continues to advance. The mainstay of treatment
remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later …

Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke

X Nie, X Leng, Z Miao, M Fisher, L Liu - Stroke, 2023 - Am Heart Assoc
Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion. However, in clinical practice, nearly half of the patients do not have …

Endovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in …

SGH Olthuis, FAV Pirson, FME Pinckaers… - The Lancet, 2023 - thelancet.com
Background Endovascular treatment for anterior circulation ischaemic stroke is effective and
safe within a 6 h window. MR CLEAN-LATE aimed to assess efficacy and safety of …

Reperfusion without functional independence in late presentation of stroke with large vessel occlusion

F Seker, MM Qureshi, MA Möhlenbruch, RG Nogueira… - Stroke, 2022 - Am Heart Assoc
Background: Reperfusion without functional independence (RFI) is an undesired outcome
following thrombectomy in acute ischemic stroke. The primary objective was to evaluate, in …

Endovascular versus medical management of posterior cerebral artery occlusion stroke: the PLATO study

TN Nguyen, MM Qureshi, D Strambo, D Strbian, S Räty… - Stroke, 2023 - Am Heart Assoc
BACKGROUND: The optimal management of patients with isolated posterior cerebral artery
occlusion is uncertain. We compared clinical outcomes for endovascular therapy (EVT) …

Mechanical thrombectomy for large ischemic stroke: a systematic review and meta-analysis

Q Li, M Abdalkader, JE Siegler, S Yaghi, A Sarraj… - Neurology, 2023 - AAN Enterprises
Background and Objectives There is growing evidence for endovascular thrombectomy
(EVT) in patients with large ischemic core infarct and large vessel occlusion (LVO). The …

Endovascular management of acute stroke

TN Nguyen, M Abdalkader, U Fischer, Z Qiu, S Nagel… - The Lancet, 2024 - thelancet.com
Stroke related to large vessel occlusion is a leading cause of disability and death worldwide.
Advances in endovascular therapy to reopen occluded arteries have been shown to reduce …

Endovascular stroke thrombectomy for patients with large ischemic core: a review

H Chen, JS Lee, P Michel, B Yan… - JAMA neurology, 2024 - jamanetwork.com
Importance Recently, 6 randomized clinical trials—RESCUE-Japan-LIMIT (Recovery by
Endovascular Salvage for Cerebral Ultra-Acute Embolism—Japan Large Ischemic Core …

The problem of restrictive thrombectomy trial eligibility criteria

TN Nguyen, J Raymond, RG Nogueira, U Fischer… - Stroke, 2022 - Am Heart Assoc
Since 2015, a series of endovascular trials transformed the management of patients with
large vessel occlusion stroke. Most thrombectomy trials used restrictive eligibility criteria to …

Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular events: a 1-year follow-up

TN Nguyen, MM Qureshi, P Klein, H Yamagami… - Neurology, 2023 - AAN Enterprises
Background and Objectives Declines in stroke admission, IV thrombolysis (IVT), and
mechanical thrombectomy volumes were reported during the first wave of the COVID-19 …