Heat-shock proteins (HSPs) are the most abundant and ubiquitous soluble intracellular
proteins. In single-cell organisms, invertebrates and vertebrates, they perform a multitude of …

MHC-class-I-presented peptides are predominantly generated by the proteasome system.
IFN-γ strongly influences the processing efficiency by inducing immunoproteasome …

The ability of killer T cells carrying the CD8 antigen to detect tumours or intracellular
pathogens requires an extensive display of antigenic peptides by major histocompatibility …

Precursors to major histocompatibility complex (MHC) class I–presented peptides with extra
NH2-terminal residues can be efficiently trimmed to mature epitopes in the endoplasmic …

The generation of many HLA class I peptides entails a final trimming step in the endoplasmic
reticulum that, in humans, is accomplished by two'candidate'aminopeptidases. We show …

Abstract Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) appears to be specialized
to produce peptides presented on class I major histocompatibility complex molecules. We …

We extended our previous genome-wide association study for psoriasis with a multistage
replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from …

We are able to make reliable predictions of the efficiency with which peptides of arbitrary
lengths will be transported by TAP. The pressure exerted by TAP on Ag presentation thus …

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an IFN-γ-induced aminopeptidase in
the endoplasmic reticulum that trims longer precursors to the antigenic peptides presented …

The loading of MHC class I molecules with their peptide cargo is undertaken by a
multimolecular peptide loading complex within the endoplasmic reticulum. We show that …