Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …

Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …

Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Multicomponent solid forms of the BCS class IV drug furosemide (FSM) were obtained upon
liquid assisted grinding with coformers anthranilamide (ANT), 4-toluamide (TOL), 2 …

Pharmaceutical cocrystals represent a distinctive class of crystal engineered
multicomponent systems consisting an API and a crystal former non-covalently linked …

A new viologen-based ionic porous organic polymer (IPOP) has been developed based on
a twisted biaryl (TMBB) as the monomer and Menshutkin reaction as the polymerization …

The marketed formulation of pazopanib (PAZ) suffers from low and variable bioavailability
because of its poor dissolution rate and photostability issues. The drug falls under …

The polymorphism of cocrystals is not studied as widely as that of single-component crystals.
In this work, two polymorphic forms of a cocrystal of melatonin with piperazine (MLT–PIP I …

The design of drug–drug multicomponent pharmaceutical solids is one the latest drug
development approaches in the pharmaceutical industry. Its purpose is to modulate the …