Muscular dystrophies constitute a group of genetic disorders that cause weakness and
progressive loss of skeletal muscle mass. Among them, Miyoshi muscular dystrophy 1 …

The rat is an important animal model for understanding gene function and developing
human disease models. Knocking out a gene function in rats was difficult until recently …

The tumor suppressor p53 is thought to play a key role in the maintenance of cell size and
homeostasis, but relatively little is known about its role in skeletal muscle. Based on its …

Skeletal muscle is composed of multinucleated, mature muscle cells (myofibers) responsible
for contraction, and a resident pool of mononucleated muscle cell precursors (MCPs), that …

Recently, researches have revealed the key roles of the cytoskeleton in the occurrence and
development of multiple diseases, suggesting that targeting the cytoskeleton is a viable …

Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that
is in urgent need of improved therapies that treat it. One of the remaining therapeutic …

It has been a long time since researchers have focused on the cytoskeletal proteins'
unconventional functions in the nucleus. Subcellular localization of a protein not only affects …

Desminopathy is the most common intermediate filament disease in humans. The most
frequent mutation causing desminopathy in patients is a R350P DES missense mutation. We …

Pathogenic variants in the DES gene clinically manifest as progressive skeletal muscle
weakness, cardiomyopathy with associated severe arrhythmias, and respiratory …

Zearalenone (ZEA) exposure has carcinogenic effects on human and animal health by
exhibiting intestinal, hepatic, and renal toxicity. At present, the underlying mechanisms on …