A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors
Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …
anticancer drug targets and their selective inhibition is highly desired for the proper …
Isatin, an endogenous nonpeptide biofactor: A review of its molecular targets, mechanisms of actions, and their biomedical implications
A Medvedev, O Buneeva, O Gnedenko, P Ershov… - Biofactors, 2018 - Wiley Online Library
Abstract Isatin (indole‐2, 3‐dione) is an oxidized indole. It is widely distributed in
mammalian tissues and body fluids, where isatin concentrations vary significantly from< 0.1 …
mammalian tissues and body fluids, where isatin concentrations vary significantly from< 0.1 …
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene) thiazolidin-2-ylidene) amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity …
Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)
thiazolidin-2-ylidene) amino) benzenesulfonamides (4a-m and 7a-g). All the newly prepared …
thiazolidin-2-ylidene) amino) benzenesulfonamides (4a-m and 7a-g). All the newly prepared …
Coordination behavior, structural, statistical and theoretical investigation of biologically active metal-based isatin compounds
Isatin-core-containing ligands were synthesized by reacting an equimolar ratio of isatin with
ethanolamine and anthranilic acid, respectively. The ligands were characterized by using FT …
ethanolamine and anthranilic acid, respectively. The ligands were characterized by using FT …
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and …
Herein we describe the design and synthesis of two series of sulfonamides featuring N-
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
[HTML][HTML] Indole derivatives as potential anticancer agents: A review
H Sachdeva, J Mathur, A Guleria - Journal of the Chilean Chemical …, 2020 - SciELO Chile
Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively
attached to produce novel drugs. Among various heterocyclic compounds, nitrogen-based …
attached to produce novel drugs. Among various heterocyclic compounds, nitrogen-based …
Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards …
Three series of indolinone-based sulfonamides (3a–f, 6a–f and 9a–f) were in vitro evaluated
as inhibitors of the tumor-associated carbonic anhydrase (CA, EC 4.2. 1.1) isoforms hCA IX …
as inhibitors of the tumor-associated carbonic anhydrase (CA, EC 4.2. 1.1) isoforms hCA IX …
Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation
On account of their significance as apoptosis inducing agents, merging indole and 3-
hydrazinoindolin-2-one scaffolds is a logic tactic for designing pro-apoptotic agents …
hydrazinoindolin-2-one scaffolds is a logic tactic for designing pro-apoptotic agents …
Recent development in indole derivatives as anticancer agents for breast cancer
K Kaur, V Jaitak - Anti-Cancer Agents in Medicinal Chemistry …, 2019 - ingentaconnect.com
Background: Breast Cancer (BC) is the second most common cause of cancer related
deaths in women. Due to severe side effects and multidrug resistance, current therapies like …
deaths in women. Due to severe side effects and multidrug resistance, current therapies like …
Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA …
Abstract Treatment of patients with triple-negative breast cancer (TNBC) is challenging due
to the absence of well-defined molecular targets and the heterogeneity of such disease. In …
to the absence of well-defined molecular targets and the heterogeneity of such disease. In …