Skeletal muscle mass is subject to rapid changes according to growth stimuli inducing both
hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic …

Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide,
emphasizing the need to develop novel therapeutic approaches. CKD predisposes to acute …

Chronic inflammation is a hallmark of cancer cachexia in both patients and preclinical
models. Cachexia is prevalent in roughly 80% of cancer patients and accounts for up to 20 …

Skeletal muscle wasting occurs in a variety of diseases including diabetes, cancer, Crohn's
disease, chronic obstructive pulmonary disease (COPD), disuse, and denervation. Tumor …

Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is
responsive to acute increases in contractile activity patterns (ie exercise) which initiate the …

Abstract PGC‐1α (peroxisome proliferator‐activated receptor gamma coactivator‐1α,
PPARGC1A) regulates the expression of genes involved in energy homeostasis and …

Studies of mitochondria-targeted nephroprotective agents suggest a key role of
mitochondrial injury in AKI. Here we tested whether an improved perception of factors …

While skeletal muscle mass is an established primary outcome related to understanding
cancer cachexia mechanisms, considerable gaps exist in our understanding of muscle …

Background Skeletal muscle mitochondria and capillaries are crucial for aerobic fitness, and
suppressed levels are associated with chronic and age-related diseases. Currently …

The inflammatory bowel disease (IBD) consisting of Crohn's disease (CD) and ulcerative
colitis (UC) are defined as idiopathic, chronic and relapsing intestinal disorders occurring in …