Abstract Deficiency of ADA2 (DADA2) is the first molecularly described monogenic vasculitis
syndrome. DADA2 is caused by biallelic hypomorphic mutations in the ADA2 gene that …

Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …

Background We observed a syndrome of intermittent fevers, early-onset lacunar strokes and
other neurovascular manifestations, livedoid rash, hepatosplenomegaly, and systemic …

Background Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that
is poorly understood. We identified six families with multiple cases of systemic and …

Objectives To analyse the prevalence of CECR1 mutations in patients diagnosed with early
onset livedo reticularis and/or haemorrhagic/ischaemic strokes in the context of inflammation …

RADAR is a two-protein bacterial defense system that was reported to defend against phage
by" editing" messenger RNA. Here, we determine cryo-EM structures of the RADAR defense …

The immunosuppressive effect of adenosine in the microenvironment of a tumor is well
established. Presently, researchers are developing approaches in immune therapy that …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Discovery of the growth factor activity of ADA2. ADAs play a pivotal role in regulating the
level of adenosine, a signaling molecule controlling a variety of cellular responses by …

Deficiency of adenosine deaminase 2 (DADA2) is a monogenic disease caused by biallelic
mutations in ADA2 gene (previously CECR1). The aim of this review was to describe the …